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ACRP ACRP-CP : ACRP Certified Professional Exam

ACRP-CP

Exam Code: ACRP-CP

Exam Name: ACRP Certified Professional Exam

Updated: Sep 30, 2026

Q & A: 127 Questions and Answers

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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Topic 1: Study Design and Conduct17%- Study implementation
  • 1. Site selection and activation
  • 2. Investigational product management
  • 3. Study monitoring and oversight
- Study planning
  • 1. Study population and eligibility criteria
  • 2. Sample size and statistical considerations
  • 3. Protocol development and amendments
Topic 2: Professionalism and Ethical Practice15%- Continuous improvement
  • 1. Professional development and education
  • 2. Quality assurance and process improvement
- Professional standards
  • 1. Confidentiality and conflict of interest
  • 2. Role responsibilities and boundaries
Topic 3: Regulatory and Compliance Requirements17%- Compliance procedures
  • 1. Regulatory submissions and approvals
  • 2. Audits and inspections
- International standards
  • 1. Declaration of Helsinki
- ICH Guidelines
  • 1. E6(R2)/E6(R3) Good Clinical Practice
  • 2. E8 General Considerations for Clinical Trials
  • 3. E2A Expedited Reporting
  • 4. E9 Statistical Principles
  • 5. E11 Pediatric Trials
Topic 4: Ethical and Participant Safety Considerations19%- Clinical care and management of research participants
  • 1. Standard of care vs protocol requirements
  • 2. Informed consent development and review
  • 3. Continuity of medical care
- Safety monitoring and reporting
  • 1. Adverse event identification and classification
  • 2. Safety information evaluation and communication
- Ethical principles
  • 1. Human subject protections and privacy
  • 2. Clinical equipoise and therapeutic misconception
Topic 5: Data Management and Informatics17%- Data quality control
  • 1. Data validation and cleaning
  • 2. Query management and resolution
- Data reporting
  • 1. Database lock and data transfer
  • 2. Data integrity and security
- Data collection
  • 1. Case report form design and completion
  • 2. Electronic data capture systems
Topic 6: Clinical Study Operations15%- Project management
  • 1. Timeline and budget management
  • 2. Vendor and stakeholder management
- Site management
  • 1. Site personnel training and delegation
  • 2. Study documentation and record keeping

ACRP Certified Professional Sample Questions:

Question #1
The PI did not record the relationship to IP in the medical chart when assessing an adverse event. The CRC noticed the omission and brought it to the PI's attention. How should this be addressed?

A. The CRC should amend the medical chart.
B. The PI should amend the medical chart.
C. The PI should notify the monitor.
D. The CRC should write a note to file.


Question #2
Which one of the following is a primary objective of a Phase III study of a new IP?

A. To demonstrate or confirm therapeutic benefit
B. To show superiority over another treatment
C. To establish dose information
D. To establish the safety profile


Question #3
Confidentiality and privacy rules for protection of human subjects at research sites are determined by the:

A. Sponsor
B. Applicable regulatory authorities
C. PI
D. Applicable site SOPs


Question #4
A deferred consent can take place in which of the following situations?

A. Only when the PI approves such a consent process immediately prior to patient enrollment, regardless of the situation being classed as emergency.
B. In an emergency situation only, when this process is described in the protocol and has received permission from the ethics committee.
C. Only when the PI approves such a consent process, regardless of the emergency situation described in the protocol.
D. In an emergency situation only, even when this process is not described in the protocol, but the sponsor approves the consent process.


Question #5
A clinical trial is conducted to measure the effectiveness of music therapy to reduce anxiety in intensive care unit patients. Patients are randomly assigned to receive headphones with music of their choice or headphones with white noise. The group receiving the white noise headphones is considered which type of control group?

A. No treatment
B. Active control
C. Placebo
D. Alternate dose


Solutions:

Question #1
Correct Answer: B
Question #2
Correct Answer: A
Question #3
Correct Answer: B
Question #4
Correct Answer: B
Question #5
Correct Answer: C

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